Blys baff
Web背景（Background）. B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and ... WebBAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been …
Blys baff
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B lymphocytes (B cells), which are part of the normal immune response, are also responsible for the over-aggressive response seen in autoimmune diseases like systemic lupus erythematosus. B cells develop in the bone marrow and continue to mature peripherally in secondary lymphoid organs and in the gut. When autoimmune B cells attack the body's own tissues, they are normally destroye… WebNov 20, 2024 · B cell activating factor of the TNF family (BAFF, also known as BLyS), a cytokine that regulates homeostasis of peripheral B cells, is elevated in the circulation of patients with autoimmune diseases such as …
WebAntibodies that detect BAFF (BLyS) can be used in several scientific applications, including Western Blot, Flow Cytometry, Immunohistochemistry, ELISA and Immunocytochemistry. … WebThe Quantikine Human BAFF/BLyS Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BAFF/BLyS in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human BAFF/BLyS and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human …
WebNov 20, 2024 · B cell activating factor of the TNF family (BAFF, also known as BLyS), a cytokine that regulates homeostasis of peripheral B cells, is elevated in the circulation of patients with autoimmune diseases such as systemic lupus erythematosus (SLE). BAFF is synthetized as a membrane-bound protein that can be processed to a soluble form after … WebJul 21, 2016 · BAFF, also called B lymphocyte stimulator (BLyS), is a B cell activation factor which is mainly expressed by monocytes, macrophages, and activated T cells. BAFF can be expressed on the cell surface as a membrane-bound form or released as a soluble form after cleavage by furin.
WebFabienne Mackay is a French Australian research immunologist and institutional leader within the Australian medical research, education and innovation sectors. [1] She is the Director and CEO of the QIMR Berghofer Medical Research Institute ( Brisbane, Queensland) since 2024, [2] after being the inaugural Head of the School of Biomedical ...
WebBAFF receptor ( B-cell activating factor receptor, BAFF-R ), also known as tumor necrosis factor receptor superfamily member 13C ( TNFRSF13C) and BLyS receptor 3 ( BR3 ), is a membrane protein of the TNF receptor superfamily which recognizes BAFF, an essential factor for B cell maturation and survival. [5] [6] In humans it is encoded by the ... blank cabinet card photosWebApr 9, 2024 · BAFF/BLyS/TNFSF13B (Catalog # 8876BF) induces mouse B cell proliferation. The ED 50 for this effect is 0.10.5 ng/mL.The ED50 for the two competitors … blank by the sea californiaWebMar 27, 2003 · BLyS/BAFF (B-lymphocyte stimulator/B-cell activating factor) is a vital B-cell survival factor. Overexpression of BLyS in mice may lead to systemic-lupus-erythematosus-like (SLE-like) disease, and BLyS overexpression is common in human SLE. Treatment of SLE-prone mice with a BLyS antagonist ameliorates disease progression and enhances … blank by alice birchWebApr 9, 2024 · BAFF/BLyS/TNFSF13B (Catalog # 8876BF) induces mouse B cell proliferation. The ED 50 for this effect is 0.10.5 ng/mL.The ED50 for the two competitors is >5 ng/mL, which is more than 25fold weaker. Recombinant Mouse BAFF/BLyS/TNFSF13B Catalog Number: 8876-BF Rev. 9/17/2024 Page 1 of 2 fram lawn mower oil filter lookupWebB-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a 32 kDa transmembrane glycoprotein in the TNF ligand superfamily. It is involved in multiple aspects of immune system regulation, particularly towards B cells (1, 2). Mature mouse BAFF consists of a 47 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane ... fram lanzarote tout inclus• Nardelli B, Moore PA, Li Y, Hilbert DM (July 2002). "B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases". Leukemia & Lymphoma. 43 (7): 1367–73. doi:10.1080/10428190290033297. PMID 12389615. S2CID 2521553. • Zhou T, Zhang J, Carter R, Kimberly R (2003). "BLyS and B cell autoimmunity". B Cell Biology in Autoimmunity. Current Directions in Autoimmunity. Vol. 6. pp. 21–37. doi:10.1159/000066854. ISBN 978-3-805… fram lawn tractor oil filtersWebApr 10, 2024 · 多数配体形成非共价同源三聚体，但ltβ（tnfsf3）与tnfβ（tnfsf1）形成异源三聚体，baff（tnfsf13b）与april（tnfsf13）形成异源三聚体。 TNF配体是膜锚定或可溶性三聚体，一般来说，一个三聚体配体与三个单体受体结合，激活细胞内信号通路。 framlingham and saxmundham cats protection