WebSep 2, 2005 · Recent studies are reviewed indicating that the transcription factor early growth response-1 (Egr1) is a direct regulator of multiple tumor suppressors including TGF β 1, PTEN, p53, and... WebFeb 23, 2024 · Background Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro …
Early growth response 1 (EGR1): a gene with as many names as
WebMar 6, 2024 · The immediate early gene and transcription factor early growth response 1 (EGR1) has thus been revealed as a major mediator and regulator of synaptic plasticity … WebJun 15, 2005 · The transcription factor early growth response 1 (Egr1) is a member of the immediate-early gene family and encodes a 59-kDa phosphoprotein observed at ∼80 … grant promoted to general of all union armies
Entry - *128990 - EARLY GROWTH RESPONSE 1; EGR1 - OMIM
EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice. See more The protein encoded by this gene belongs to the EGR family of Cys2His2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for … See more The DNA-binding domain of EGR-1 consists of three zinc finger domains of the Cys2His2 type. The amino acid structure of the EGR-1 zinc … See more EGR-1 has been shown to interact with: • CEBPB, • CREB-binding protein, • EP300, • NAB1, See more • Zif+268+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook Egr-1 See more EGR-1 binds the DNA sequence 5'-GCG TGG GCG-3' (and similar ones like 5'-GCG GGG GCG-3'). The f1 position 6 binds the 5' G (the first base count from the left); the f1 position 3 to the second base (C); f1 position -1 binds to the third position (G); f2 … See more • Zinc finger See more • Heath RG (March 1975). "Brain function and behavior. I. Emotion and sensory phenomena in psychotic patients and in experimental … See more WebMar 30, 2024 · One of the several host-factors that contribute to bacterial adhesion and the outcome of an infection is the activation of early growth response 1 (EGR1). EGR1 is … WebMar 8, 2024 · Here, through integrative genomic approaches, we identify the immediate-early gene EGR1 as a positive transcriptional regulator of TFEB expression in human cells and demonstrate that, in the absence of EGR1, TFEB-mediated transcriptional response to starvation is impaired. grant property mgmt