Gemcitabine and ferroptosis

Author: wfjt

August undefined, 2024

WebMar 4, 2024 · Accumulating studies have implicated that dysfunctional ferroptosis is involved in the progression of numerous human diseases and pathogenic processes 12, including carcinogenesis,... WebMany chemotherapeutic drugs can induce ferroptosis in addition to their primary action (e.g., cisplatin, gemcitabine, sorafenib); in preclinical cancer models their action is increased by co-treatment with ferroptosis inducers, such as drugs that inhibit System Xc −, reduce GSH, inhibit GPX4, or alter intracellular iron levels (Su et al ...

The interaction between ferroptosis and lipid metabolism …

WebJun 30, 2024 · Abstract. Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have … WebApr 12, 2024 · Ferroptosis combined with immunity shows a pivotal role in a variety of tumors, which provides new opportunities to detect and treat breast cancer.Methods: Our first step was to combine multiple datasets to search for immune ferroptosis-related mRNAs. ... Doxorubicin, Cisplatin, Gemcitabine, Gefitinib, Imatinib, Vinorelbine) in … purchase wooden dummy

A novel natural killer cell-related signatures to predict prognosis …

WebMay 13, 2024 · Ferroptosis is a novel and unique non-apoptotic cell death form, which is different from apoptosis, necrosis and autophagy, involving iron-dependent ROS formation and lipid oxidation (Yang and Stockwell, 2016). Activation of ferroptosis observed in cancer contributed to destroying the cancer cells (Dixon et al., 2012). Web1 Introduction. Pancreatic cancer (PC) as a lethal malignancy shows a high mortality worldwide, causing over 331000 deaths per year globally (Rawla et al., 2024).Although advances in the treatment of PC, patients who received surgical resection have a five-year survival rate ranging from 10% to 25% (Siegel et al., 2024).PC was usually diagnosed at … WebGemcitabine (GEM), an antimetabolite that terminates DNA synthesis, is commonly used in the treatment of cancers including lung adenocarcinoma (LUAD). However, … purchase woodcock johnson iv

Targeting Ferroptosis Pathway to Combat Therapy Resistance and ...

Natural products in digestive tract tumors metabolism: Functional …

WebJan 24, 2024 · Gemcitabine pretreatment inhibits ferroptosis in diverse cell types. Cell death in p53 wild-type Caki-1 cells and p53 mutant H1299 cells upon treatment with the indicated conditions. Nutlin-3 and gemcitabine were used as pretreatments for 48 h before addition of erastin2. Cell death was measured 24 h (Caki-1) or 36 h (H1299) after … WebJan 1, 2024 · Activation of ferroptosis or apoptosis could potentiate cytotoxic effect of gemcitabine, while FBW7 promoted both ferroptosis and apoptosis. Thus, we … secret santa ideas for a manWebFerroptosis is a newly identified form of regulated cell death and is mainly driven by iron-mediated oxidative damage, ... Results showed that patients in the high-risk group had lower IC50s of cisplatin, doxorubicin, gemcitabine, mitomycin C, etoposide, and paclitaxel than those in the low-risk group, which suggested that patients with high ... purchase wood burning stove

"WebMay 24, 2024 · Docetaxel resistance seriously affects its clinical application in prostate cancer (PCa). Ferroptosis is a type of iron-dependent cell death driven by lipid … " - Gemcitabine and ferroptosis

Gemcitabine and ferroptosis

Ferroptosis: At the Crossroad of Gemcitabine Resistance …

WebApr 1, 2024 · Moreover, little literatures explored the relationship between ferroptosis and gemcitabine. Therefore, it is urgent to investigate the underlying effect of ferroptosis on pancreatic cancer and the promising value on cancer therapy. ARF6 belongs to the Ras superfamily and encodes small guanine nucleotide-binding proteins (GTP-binding protein). WebMay 20, 2024 · The mechanism of ferroptosis mainly relies on intracellular dynamically balanced biochemical processes: the production and elimination of lipid peroxides. In these processes, iron and polyunsaturated fatty acids (PUFAs) are used as raw materials for lipid peroxidation to promote ferroptosis.

Did you know?

WebGemcitabine (GEM) was employed to promote ferroptosis, and ferroptosis levels were determined by monitoring lipid reactive oxygen species (ROS), cell survival, and intracellular Fe 2+ concentrations. To assess in vivo tumor response to GEM therapy, a xenograft tumor mouse model was utilized.

WebOct 10, 2024 · Ferroptosis has been found to play a role in different cancers, including head and neck, and pancreatic cancer and hepatocellular carcinoma. … WebJul 9, 2007 · Gemcitabine is the only cytotoxic agent approved by FDA for the treatment of pancreatic carcinoma. Gemcitabine has a relatively safe profile. Major side effects …

WebDec 16, 2024 · Furthermore, the patients with low-ferroptosis scores have a lower estimated IC50 in the several chemotherapy drugs, including paclitaxel, gemcitabine, and methotrexate. Conclusions: We revealed that sex hormone receptors and immune cell infiltration were markedly different between ferroptosis subtypes in GC patients. WebNov 13, 2024 · Ferroptosis is characterized by iron-dependent accumulation [ 9 ]. Thus, intracellular iron levels were determined in HCT116 and DLD-1 cells by using a Fe 2+ iron probe known as FerroOrange. The...

WebApr 7, 2024 · In GSE72094 dataset, Oxeiptosis score was highest in StageⅢ, and Ferroptosis and Necroptosis scores were greater in patients with age>60 . FIGURE 6. FIGURE 6 ... docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer. Health Technol. Assess. Winch. Engl. 5 (32), 1–195. doi:10.3310/hta5320. CrossRef Full Text …

WebAug 31, 2024 · On one hand, ATF4-mediated HSPA5 expression prevents the degradation of GPX4, thereby increasing the resistance of pancreatic cancer cells or glioma cells to ferroptosis caused by gemcitabine or ... secret santa hint ideasWebA growing body of evidence shows that ferroptosis plays a complex role in cancer, depending on the stage and the microenvironment of the tumor. While the current data are only preclinical, ferroptotic cell death may play a dual role in inhibiting or promoting PDAC formation during oncogenic KRAS activation. secret santa is comingWebDOI号:10.1016文献链接:j.bcp.2024.114813文献作者:备注信息: Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells secret santa ideas listWebApr 1, 2024 · Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. purchase woolworths gift cardWebApr 15, 2024 · Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely … purchase world globe onlineWebAug 29, 2024 · It is tightly coupled to the regulation of protein interactions, trafficking, degradation, and enzymatic activities, thereby affecting a wide spectrum of cellular processes, including ferroptosis, lysosomal degradation, DNA repair, apoptosis, and other diverse processes 15-17. purchase word processing softwareWebOct 10, 2024 · In this article, we reviewed gemcitabine-resistance mechanisms; assessed the relationship among ferroptosis, tumorigenesis and gemcitabine resistance, and … purchase wooden micro houses