How is sertraline distributed by the body
Web8 apr. 2024 · Sertraline is metabolized at least in part by the liver, mainly via the cytochrome P450 system and PYP 2D6 and 2B6 which can cause drug-drug … Web20 sep. 2024 · By Catriona Harvey-Jenner Published: 20 September 2024. Scientists researching Sertraline have discovered the antidepressant may actually function …
How is sertraline distributed by the body
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WebWhen female rats received sertraline during the last third of gestation and throughout lactation, there was an increase in stillborn pups and pup deaths during the first 4 days after birth. Pup body weights were also decreased during the first four days after birth. These effects occurred at a dose of 20 mg/kg (0.8 times the MRHD on a mg/m2 basis). Web12 dec. 2024 · It is used to treat obsessive-compulsive problems. It is used to treat panic attacks. It is used to treat post-traumatic stress. It is used to treat mood problems caused by monthly periods. It is used to treat social anxiety problems. It may be given to your child for other reasons. Talk with the doctor.
Web22 jan. 2024 · Typically, nerve cells in the brain and spinal cord produce serotonin that helps regulate attention, behavior and body temperature. Other nerve cells in the body, primarily in the intestines, also produce serotonin. Serotonin plays a role in regulating the digestive process, blood flow and breathing. Web24 feb. 2024 · Zoloft (sertraline) may lead to a small weight gain ranging from 1% to 1.6% of initial body weight when used over 6 months to 1 year. In the short-term, weight gain …
Web1 feb. 2002 · The relationships between sertraline daily dosage and serum concentrations (rs = 0.67, P < 0.0001) as well as between body weight normalized daily doses and … Web7 jul. 2024 · Sertraline undergoes extensive first-pass hepatic metabolism. Based on clinical and in-vitro data, it can be concluded that sertraline is metabolized by multiple pathways including CYP3A4, CYP2C19 (see section 4.5) and CYP2B6. Sertraline and its major metabolite desmethylsertraline are also substrate of P-glycoprotein in-vitro. Elimination
WebSertraline is widely distributed, and its volume of distribution is estimated to be more than 20L/kg. 6 Post-mortem studies in humans have measured liver tissue concentrations of 3.9–20 mg/kg for sertraline and between 1.4 to 11 mg/kg for its active metabolite, N … Back to Sertraline. Indications Status Purpose Phase; DBCOND0018735 … Sertraline Withdrawn Phase N/A Trials for Depression . Back to Sertraline. … Sertraline: A selective serotonin reuptake inhibitor (SSRI) indicated to treat major …
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