Human ifn beta
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IFN-α and IFN-β are secreted by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts and others. They stimulate both macrophages and NK cells to elicit an anti-viral response, involving IRF3/IRF7 antiviral pathways, and are also active … See more The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is … See more The mammalian types are designated IFN-α (alpha), IFN-β (beta), IFN-κ (kappa), IFN-δ (delta), IFN-ε (epsilon), IFN-τ (tau), IFN-ω (omega), and IFN-ζ (zeta, also known as limitin). Of these types, IFN-α, IFN -ω, and IFN-τ can work across species. See more One of the major limiting factors in the efficacy of type I interferon therapy are the high rates of side effects. Between 15% - 40% of people undergoing type 1 IFN treatment develop major depressive disorders. Less commonly, interferon treatment has also … See more Avian type I IFNs have been characterized and preliminarily assigned to subtypes (IFN I, IFN II, and IFN III), but their classification into subtypes should await a more extensive characterization of avian genomes. Functional lizard … See more Therapeutics From the 1980s onward, members of type-I IFN family have been the standard care as … See more In cancer From the 1980s onward, members of type-I IFN family have been the standard care as immunotherapeutic agents in cancer therapy. In … See more Interferonopathies are a class of hereditary auto-inflammatory and autoimmune diseases characterised by upregulated type 1 interferon and downstream interferon … See more Web29 Nov 2024 · IFN-I is the key regulatory component activating and modulating the response of innate and adaptive immune system to bacterial as well as viral pathogens. IFN-I promotes the expression of IFN-induced genes (ISG) and, consequently, the production of chemokines, e.g., CXCL10. Those chemokines control migration and localization of …
Human ifn beta
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WebHuman Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN … WebIFN-beta, IFNB1, Fibroblast interferon, IFBIFNB, IFF, IFN-beta, interferon beta. Detection method: Sandwich ELISA, Double Antibody. Application: This immunoassay kit allows for …
WebIFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis. Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt. Customers Who Viewed This Item Also Viewed... Recombinant Human WebInterleukin-6 (IL-6/BSF-2/IFNβ 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune …
WebIFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis. Rigorous validation Each manufactured lot of this ELISA kit is quality tested … WebThis is the 3rd WHO International Standard for glycosylated human interferon beta (IFN-β) and is intended for use as the primary biological reference standard in bioassays for glycosylated human IFN-β. The unitage of 00/572 is continuous with that of the 2nd International Standard, Gb23-902-531, and therefore 00/572 is suitable to serve as a ...
WebHuman IFN-Beta 1a, mammalian, carrier-free Catalog Number: 11410 Useful for MS research studies, recombinant Human IFN-Beta 1a protein is expressed in CHO cells. $620.00 Pack Size 1 x 10⁶ units 11410-2 Quantity Add to cart Product Info Supplied without a carrier protein and as a liquid to maintain higher specific activity. Specifications Citations
Web induction agaWeb20 May 2024 · Human interferon beta is a polypeptide used in the management of relapsing forms of Multiple Sclerosis (MS), and was initially approved by the FDA in 1992. 9 Multiple Sclerosis is a devastating neurodegenerative disease that is usually progressive and significantly debilitating with a profound impact on the quality of life. 3 log analytics delete custom tableThe AlphaLISA® Human Interferon β (IFN-β) Detection Kit is designed for detection and quantitation of human IFN-β in serum, buffered solution or cell … log analytics extension versionWebIFN‑ alpha / beta R1, in association with IFN‑ alpha / beta R2, is required for propagating anti‑microbial signal transduction triggered by the type 1 interferons such as IFN‑ alpha and IFN‑ beta (2, 3). Mature human IFN‑ alpha / beta R1 consists of a 409 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 100 aa ... log analytics disaster recoveryWeb20 May 2024 · Human and monkey IFN-β protein concentration was measured using human IFN-β Quantikine ELISA Kits (R&D Systems) per manufacture’s protocol. Mouse … log analytics free tierWebMouse anti Human IFN beta antibody, clone F03-2G4, recognizes interferon beta (IFN beta) also known as fibroblast interferon, a type I interferon. It is constitutively … induction agendaWebIFN beta is a member of type I family of interferons. It binds to the IFNα/β receptor (IFNAR), activating the Jak/ STAT pathway. Activation of this signaling pathway results in upregulating genes that inhibit viral infection and regulate MHC class I antigens. It is primarily produced by fibroblasts and monocytes. log analytics free