Phospholipidosis heart

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August undefined, 2024

WebM. Narváez-Rivas, M. León-Camacho, in Encyclopedia of Food and Health, 2016 Phospholipids. Phospholipids are a class of lipids that have two fatty acyl molecules … WebFeb 18, 2014 · Phospholipidosis (PLD) is characterized by an intracellular accumulation of phospholipids in lysosomes and concurrent development of concentric lamellar bodies. It …

Cardiac Muscle Cell - an overview ScienceDirect Topics

WebPhospholipidosis induced by drugs with a cationic amphiphilic structure is a generalized condition in humans and animals that is characterized by an intracellular accumulation of phospholipids and the concurrent development of concentric lamellar bodies. WebPhospholipidosis (PLD) is characterized by excessive intra-cellular accumulation of phospholipids, with a distinct mor - phological appearance of lamellar bodies visible under an electron microscope (EM).1 Drugs, including many antibi-otics, antidepressants, and antihistamines, induce PLD in various tissues such as lung,2 heart,3 liver,4 and ... iphone facility crossword clue

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WebApr 2, 2013 · Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A... WebMar 24, 2024 · Correlations between phospholipidosis (DIPL), normalized to amiodarone at 100%, and percent of SARS-CoV-2, normalized to DMSO at 100%, in the RT-qPCR assay in A549-ACE2 cells. ... National Heart ... WebDec 14, 2009 · Phospholipidosis in neurons, the heart, or the eyes might generate more safety concerns. A drug that has the potential to induce PL in terminally differentiated organs such as the eye, the heart, and neurons may require additional monitoring in … iphone facetime on windows

Phospholipidosis - an overview ScienceDirect Topics

Phospholipid - an overview ScienceDirect Topics

WebMar 23, 2024 · Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2 Drug-induced phospholipidosis is a single mechanism that may explain the in vitro efficacy of a wide-variety of therapeutics repurposed for COVID-19. WebLipid Management services at the Massachusetts General Hospital Corrigan Minehan Heart Center care for patients who have disorders of lipid metabolism, which include high … orange business service malaysiaWebJan 1, 1997 · Phospholipids are structural components of mammalian cytoskeleton and cell membranes. The metabolism of this essential cell component is regulated by the individual cell and may be altered by drugs that interact with phospholipids or the enzymes that affect their metabolism. iphone facetime android

"WebOct 23, 2016 · Phospholipidosis was characterized light microscopically by cytoplasmic enlargement with multivesicular vacuolation of bile ductular epithelium in the liver or the presence of a large clear vacuole occupying the cytoplasm of distal tubular epithelium of the kidney . Glomeruli of the affected kidney appeared to have a few small clear-appearing ... " - Phospholipidosis heart

Phospholipidosis heart

WebPhospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of intracellular phospholipids in tissues, such as the liver, kidney and lung. It is well established 1 that a large number of cationic amphiphilic drugs have the potential to induce phospholipidosis. WebCardiac muscle cells can be affected in the generalized form of drug-induced phospholipidosis, which is characterized by the presence of typical lamellate or crystalloid and membrane-bound inclusions.

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Webphospholipidosis and on a 10-fold cross-validation test produced {76% positive, 78% negative predictivity} and {65% positive, 87% negative predictivity}, respectively. All these approaches are based on relatively simple models, and as phospholipidosis is clearly a complex effect, applying state of the art machine learning techniques could therefore WebJan 21, 2024 · Fabry disease (FD) is a genetic disorder caused by a-galactosidase A gene mutation. Ultrastructural analysis revealing zebra bodies are the typical morphological characteristics. However, certain tricyclic antidepressants and some other medications could induce renal phospholipidosis mimicking FD. We report a 33-year-old man has been …

WebDec 1, 2006 · A 76-year-old male Caucasian patient was treated in our hospital for acutely decompensated heart failure due to restrictive cardiomyopathy. ... Drug-induced phospholipidosis is characterized by ... WebOct 9, 2006 · Drug-induced phospholipidosis. Drug-induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most …

WebMar 24, 2024 · Drug-induced phospholipidosis: Human: ASCs: Matrigel: Expression of CYP450 enzyme (CYP3A4); ... heart, and kidney.86 Yang et al57 showed that human PSC (hPSC)–derived hepatocyte and cholangiocyte organoids expressing angiotensin 1 converting enzyme 2 (ACE2, a putative receptor of SARS-CoV-2) were highly permissive to … WebFeb 22, 2024 · The topic of lysosomal accumulation was chosen for several reasons: (1) this change is frequently encountered in nonclinical toxicity studies (Logan et al. 2012) due to the central role of lysosomes in cellular uptake, storage, intracellular trafficking, and digestion of endogenous and exogenous material; (2) it is caused by a wide variety of …

WebThe level of OA in plasma phospholipids in Greece, Italy, and Spain, where olive oil consumption is high, is from 11.2% to 12.7% of total FA. On the other hand, in other …

WebJun 22, 2024 · Phospholipidosis depends on the physicochemical properties of drugs and does not reflect specific target-based activities—rather, it may be considered a toxic … orange business service logoWebPhospholipidosis (PL) is a phospholipid storage disorder, resulting in excessive accumulation of phospholipids in lysosomes of various tissue types [199, 200]. There is a general agreement that inhibition of lysosomal phospholipase A1, A2 and/or C contributes to the accumulation of cationic amphiphilic drug (CADs)–phospholipid complexes. iphone facetime says waiting for activationWebJan 20, 2024 · Phone: 734-449-1190 Mucolipidosis IV (ML 4) Foundation Phone: 877-654-5459 National MPS Society Phone: 919-806-0101 National Organization for Rare … orange business service commercialWebMay 1, 2024 · Phospholipidosis (PL) describes the accumulation of phospholipids in lysosomes of cells of various tissues after prolonged exposure with drug like compounds. These cellular findings can result in a delay of drug development, cause increased costs in affected projects and potentially may halt a drug development program. The early … iphone facetime 使い方WebDec 18, 2024 · Abstract. Drug-induced phospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of phospholipids. Its cellular mechanism is still … iphone factory chinaWebNumerous targets — including G protein-coupled in vitro phospholipidosis (PLD)50, which is commonly used either receptors, transporters, ion channels, nuclear receptors and kinases prospectively to screen out potential PLD inducers, or retrospectively — have been associated with significant side effects in non-clinical or to explain the ... iphone factory reset software free downloadWebPhospholipidosis (PL) is lysosomal storage disorder characterized by the excessive accumulation of intracellular phospholipids (Figure 1). The mechanism of … iphone factory carrier